Clinical Evaluation of Cox-2 Inhibitor for Management of Post Operative Complications after Odontectomy of Impacted Lower Third Molar

Aim: to compare the efficacy of cox-2 inhibitor (celebrex) with NSAID (ibuprofen) on the postoperative complications after odontectomy of impacted lower third molar which are pain edema and trismus. Patients and Methods: atotal of 40 patients (20 males, 20 females) with impacted lower third molar divided into two equal groups. Group I: twenty patients treated with 600 mg/12h ibuprofen, GroupII: twenty patients treated with 200mg/12 h celebrex. Results: the results showed that compared with NSAID (ibuprofen) cox-2 inhibitor(celebrex) had superior analgesic effect on all measures of analgesic efficacy, in the 1 day post-operative it was 4.35 ± 1.14 in the NSAID group and 3.05 ± 1.64 in the cox-2 inhibitor group with p-value 0.01 * but at the 3 days post-operative it was 1.60 ± 2.04 in the NSAID group and 0 in the cox-2 inhibitor group with pvalue 0.03 *, but there is no significant difference in the assessment of edema and trismus between the two groups. Conclusion: cox-2 inhibitor (celebrex) had superior analgesic effect when compared with the traditional NSAID (ibuprofen) but there is no significant difference between them in reduction of edema and trismus. [Shimaa S. Ahmed; Eman. A. ElSharrawy and Tamer. A. Hamed. Clinical Evaluation of Cox-2 Inhibitor for Management of Post Operative Complications after Odontectomy of Impacted Lower Third Molar. J Am Sci 2014;10(11):60-63]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 9